The Marcus Foundation Gives $20 Million to Grady Health System

/PRNewswire/ -- The Marcus Foundation today announced a $20 million gift to Grady Health System to improve emergency care to trauma and acute neurological injury victims throughout Georgia. The gift will enable Grady to expand hospital space for trauma and brain injury victims and improve time-dependent therapies for stroke and acute neurological emergencies. The new facilities will be named The Marcus Stroke & Neuroscience Center at Grady and The Marcus Trauma Center at Grady.

The project involves renovating existing hospital space to expand Grady's Trauma Center capacity from four to six dedicated trauma bays with the proper equipment, space, and resuscitation capacity to enhance life-saving patient care. Patients could then be transferred for two to ten days of care in a new 20-bed Neuro Intensive Care Unit. The funding will cover the cost of construction, equipment and recruitment of five key physicians to support the facilities.

"This gift provides us the capital to expand and modernize Grady's Trauma Center and build a new Neuro Intensive Care Unit in existing unused hospital space," said Grady President and CEO Michael Young. "These improvements will enable Grady to advance its already strong trauma care services and provide cutting-edge acute emergency care for traumatic brain injury and stroke patients. In addition to improving care, the Neuro ICU program's solid reimbursement rates should contribute greatly to Grady's ongoing fiscal sustainability."

"Grady will now be able to offer metro Atlanta a much needed 'go to' facility for neurological emergencies that operates 24 hours a day," said Bernie Marcus, chairman of the Marcus Foundation. "It is imperative to other hospitals and services throughout Atlanta and Georgia, including the Shepherd Center's Acquired Brain Injury Program and the Marcus Community Bridge Program, that Grady continues to be the leader in trauma and acute care, with the most skilled medical personnel and most updated equipment. And we hope this donation encourages others to make funding commitments to enable this facility to continue doing so much good for all those it touches."

"We have stressed for years how vital Grady is to healthcare here in metro Atlanta and across the state. I think this gift from the Marcus Foundation is recognition not only of Grady's current status but also of its remarkable potential," said A.D. "Pete" Correll, chairman of Grady Memorial Hospital Corp., which oversees Grady Health System. "Personally, I am touched by the magnitude of Bernie and Billi's gift and professionally, I look forward to seeing its impact on a team that has proven it can translate research findings to clinical outcomes."

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FDA Funds Emory-Led Critical Care Lung Research at Grady Hospital

A new study funded by the U.S. Food and Drug Administration is underway by Emory physicians at Grady Memorial Hospital to find an effective treatment for patients with acute lung injury.

Lead study investigator Greg S. Martin, MD, says despite less than 200,000 reported cases each year, "acute lung injury is not an uncommon disease for critically ill patients. Every published study notes that between 10 and 25 percent of critically ill patients have this disease, and it's something we see frequently in the ICU." Martin is assistant professor of medicine (pulmonary, allergy and critical care medicine) in Emory University School of Medicine,

Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are inflammatory disorders of the lung most commonly caused by sepsis, pneumonia, trauma and/or aspiration.

"These disorders can elicit an immune response that creates such an exaggerated amount of inflammation that the lung becomes injured," says Martin. "When the lung becomes injured it doesn’t work properly and gas exchange doesn’t occur normally. People with this severe form of lung injury end up on a respirator and there is no real treatment."

Previous clinical trials have shown that combination colloid and diuretic therapy greatly improves oxygenation and fluid balance in ALI/ARDS patients without compromising their cardiovascular stability.

In this study, Martin and his team will follow 60 patients, comparing two drug combinations that have not previously been assessed. In a randomized, double-blind, controlled design, 30 patients will receive continuous infusion furosemide with 5 percent albumin and 30 patients will receive 6 percent hetastarch. The treatment will last for five days and patients will be assessed during and afterwards for improvements in lung function and dependence on the mechanical respirator.

Martin says these specific drug combinations were chosen because they are very complementary. Studying their interactions will give researchers a better understanding of the biochemistry and physiology of the disease.

“These drugs should help to resorb some of the excess fluid in the lung from ALI/ARDS as well as improve some of the inflammation and other stress that the body withstands, and thus improve gas exchange from the lung," he says. "If we’re right about some of the preliminary data, this treatment could reduce the length of time on the ventilator."

In ALI the lung is injured and develops a thick fluid that accumulates in the lungs and causes swelling or edema. Current strategies attempt to remove that edema or block the inflammation that causes the edema.

Treatment includes mechanical ventilation, supportive care and treatment of underlying causes, but Martin notes, “Studies of ALI or ARDS over the past 30 years have all failed to find anything that is directly effective. At Emory we’ve been working for a number of years on strategies that help prevent the accumulation of edema to start with and affect the way fluid might be removed more quickly."

According to Martin, the mortality rate for patients with ALI and ARDS is approximately 40 percent. Those who survive usually are on a ventilator for several weeks, often resulting in severe consequences, including weakness, brain impairment and reduced quality of life.

“ALI is a relatively common condition in the ICU for which there is no treatment," says Martin. "We’re hoping to find something that will get people off the ventilator sooner and perhaps improve their outcome. Unfortunately, individuals must be critically ill to be eligible for this study – they cannot volunteer on their own. However, it is important for people to know that Emory University and Grady Memorial Hospital are working hard on something that really can make a difference for these patients.”

Martin treats patients in both pulmonary and critical care medicine at Grady Memorial Hospital, Emory Crawford Long Hospital and Emory University Hospital. He also trains fellows in pulmonary and critical care medicine and directs the Medical and Coronary Intensive Care Units at Grady Memorial Hospital.